Publications
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Thomas Willems, Melissa Gymrek, G David Poznik, Chris Tyler-Smith, 1000 Genomes Project Chromosome Y Group, Yaniv Erlich. (2016) Population-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates. Am J Hum Genet. [pubmed] [bibtex]
G David Poznik, Yali Xue, Fernando L Mendez, Thomas F Willems, Andrea Massaia, Melissa A Wilson Sayres, Qasim Ayub, Shane A McCarthy, Apurva Narechania, Seva Kashin, Yuan Chen, Ruby Banerjee, Juan L Rodriguez-Flores, Maria Cerezo, Haojing Shao, Melissa Gymrek, Ankit Malhotra, Sandra Louzada, Rob Desalle, Graham R S Ritchie, Eliza Cerveira, Tomas W Fitzgerald, Erik Garrison, Anthony Marcketta, David Mittelman, Mallory Romanovitch, Chengsheng Zhang, Xiangqun Zheng-Bradley, Gonçalo R Abecasis, Steven A McCarroll, Paul Flicek, Peter A Underhill, Lachlan Coin, Daniel R Zerbino, Fengtang Yang, Charles Lee, Laura Clarke, Adam Auton, Yaniv Erlich, Robert E Handsaker, The 1000 Genomes Project Consortium, Carlos D Bustamante, Chris Tyler-Smith. (2016) Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences. Nature Genetics. [pubmed] [bibtex]
Javier Quilez, Audrey Guilmatre, Paras Garg, Gareth Highnam, Melissa Gymrek, Yaniv Erlich, Ricky S. Joshi, David Mittelman, Andrew J. Sharp. (2016) Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans. Nucleic Acids Research. [pubmed] [bibtex]
Melissa Gymrek, Thomas Willems, Haoyang Zeng, Barak Markus, Mark J Daly, Alkes L Price, Jonathan Pritchard, Yaniv Erlich. (2015) Abundant contribution of short tandem repeats to gene expression variation in humans. Nature Genetics. [pubmed] [bibtex]
Nicolo Riggi, Birgit Knoechel, Shawn M. Gillespie, Esther Rheinbay, Gaylor Boulay, Mario L. Suva, Nikki E. Rossetti, Wannaporn E. Boonseng, Ozgur Oksuz, Edward B. Cook, Aurelie Formey, Anoop Patel, Melissa Gymrek, Vishal Thapar, Vikram Deshpande, David T. Ting, Francis J. Hornicek, G. Petur Nielsen, Ivan Stamenkovic, Martin J. Aryee, Bradley E. Bernstein, Miguel N. Rivera. (2014) EWS-FLI1 Utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing Sarcoma. Cancer Cell. [pubmed] [bibtex]
Melissa Gymrek. (2014) PyBamView: a browser based application for viewing short read alignments. Bioinformatics. [pubmed] [bibtex]
Thomas F. Willems, Melissa Gymrek, Gareth Highnam, The 1000 Genomes Project, David Mittelman, Yaniv Erlich. (2014) The Landscape of Human STR Variation. Genome Res. [pubmed] [bibtex]
Dina Zielinski, Barak Markus, Mona Sheikh, Melissa Gymrek, Clement Chu, Marta Zaks, Balaji Srinivasan, Jodi D. Hoffman, Dror Aizenbud, Yaniv Erlich. (2014) OTX2 Duplication Is Implicated in Hemifacial Microsomia. PLoS One. 9(5):e96788 [pubmed] [bibtex]
Michal Breker, Melissa Gymrek, Ofer Moldavski, Maya Schuldiner. (2013) LoQAtE--Localization and Quantitation ATlas of the yeast proteomE. A new tool for multiparametric dissection of single-protein behavior in response to biological perturbations in yeast. Nucleic Acids Res. 0(0):0 [pubmed] [bibtex]
Melissa Gymrek, Yaniv Erlich. (2013) Profiling short tandem repeats from short reads. Methods Mol Biol. 1038(0):113-35 [pubmed] [bibtex]
Michal Breker, Melissa Gymrek, Maya Schuldiner. (2013) A novel single-cell screening platform reveals proteome plasticity during yeast stress responses. J Cell Biol. 200(6):839-50 [pubmed] [bibtex]
Melissa Gymrek, Amy McGuire, David Golan, Eran Halperin, Yaniv Erlich. (2013) Identifying personal genomes by surname inference. Science. 339(6117):321-4 [pubmed] [bibtex] Press and resources
Dina Zielinski, Melissa Gymrek, Yaniv Erlich. (2012) Back to the family: a renewed approach to rare variant studies. Genome Med. 4(12):97 [pubmed] [bibtex]
Carlos Sebastian, Bernadette Zwaans, Dafne Silberman, Melissa Gymrek, Alon Goren, Lei Zhong, Oren Ram, Jessica Truelove, Alexander Guimaraes, Debra Toiber, Claudia Cosentino, Joel Greenson, Alasdair MacDonald, Liane McGlynn, Fraser Maxwell, Joanne Edwards, Sofia Giacosa, Ernesto Guccione, Ralph Weissleder, Bradley Bernstein, Aviv Regev, Paul Shiels, David Lombard, Raul Mostoslavsky. (2012) The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 151(6):1185-99 [pubmed] [bibtex]
Michal Nadler-Holly, Michal Breker, Ranit Gruber, Ariel Azia, Melissa Gymrek, Miriam Eisenstein, Keith Willison, Maya Schuldiner, Amnon Horovitz. (2012) Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis. Proc Natl Acad Sci U S A. 109(46):18833-8 [pubmed] [bibtex]
Melissa Gymrek, David Golan, Saharon Rosset, Yaniv Erlich. (2012) lobSTR: A short tandem repeat profiler for personal genomes. Genome Res. 22(6):1154-62 [pubmed] [bibtex] lobSTR website
Melissa Gymrek, Yaniv Erlich. (2012) Using DNA sequencers as stethoscopes. Genome Med. 3(11):73 [pubmed] [bibtex]
Oren Ram, Alon Goren, Ido Amit, Noam Shoresh, Nir Yosef, Jason Ernst, Manolis Kellis, Melissa Gymrek, Robbyn Issner, Michael Coyne, Timothy Durham, Xiaolan Zhang, Julie Donaghey, Charles Epstein, Aviv Regev, Bradley Bernstein. (2011) Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell. 147(7):1628-39 [pubmed] [bibtex]
Kristen Naegle, Melissa Gymrek, Brian Joughin, Joel Wagner, Roy Welsch, Michael Yaffe, Douglas Lauffenburger, Forest White. (2010) PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies. Mol Cell Proteomics. 9(11):2558-70 [pubmed] [bibtex]
Fatih Ozsolak, Alon Goren, Melissa Gymrek, Mitchell Guttman, Aviv Regev, Bradley Bernstein, Patrice Milos. (2010) Digital transcriptome profiling from attomole-level RNA samples. Genome Res. 20(4):519-25 [pubmed] [bibtex]
Alon Goren, Fatih Ozsolak, Noam Shoresh, Manching Ku, Mazhar Adli, Chris Hart, Melissa Gymrek, Or Zuk, Aviv Regev, Patrice Milos, Bradley Bernstein. (2009) Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA. Nat Methods. 7(1):47-9 [pubmed] [bibtex]